Viral delivery of small interfering ribonucleic acid (RNA) to p22phox, a critical membrane component of NADPH oxidase, has been shown to inhibit choroidal neovascularization in a mouse model of AMD, confirming the role of NADPH oxidase in ROS production and its potential as a therapeutic target [10]. The gene discussed is FMO5; the disease is age-related macular degeneration.