There have been many studies on aerobic glycolysis and HCC, and a variety of factors such as Adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK), c-Myc, and hypoxia inducible factor-1 (HIF-1α) are involved in the regulation of metabolic reprogramming, which has an impact on the development and progression of HCC.11 Here, MYC is linked to hepatocellular carcinoma.