ABCC1 and cancer: The EMT process facilitates cancer cells’ survival even after chemotherapy and promotes aggressive lung metastases by enduring tolerance through the activation of chemoresistance-related genes including drug transporters like ABCB1a, ABCB1b, and ABCC1. Inhibition of EMT has been shown to reduce chemotherapy resistance such as in breast-to-lung metastasis orthotopic mice models where overexpression of mirR-200 reduced cyclophosphamide resistance (107).