PCA3 and cancer: (21) assessed the value of urine prostate cancer antigen 3 (PCA3) for screening PCa in men, and the results showed that urine PCA3 plays an important role in reducing the medical burden of men undergoing repeat prostate biopsies, and for men who have not undergone a biopsy, a high PCA3 score significantly increases the likelihood of detecting cancer in the initial prostate biopsy.