In the in vivo experiment, compared with the normal group, the serum levels of IL-6 and TNF-α in the DM group were significantly increased, and Sitagliptin phosphate and insulin intervention inhibited the serum levels of IL-6 and TNF-a (Figures 2D, F, P <0.05); compared with insulin intervention, Sitagliptin phosphate improved the decreased expression of IL-10 in DM mice (Figure 2E, P <0.05). This evidence concerns the gene IL10 and diabetes mellitus.