In this study, IFNα, IFNβ, ISG15, USP18, IFN-induced protein 44 (Ifi44), interferon-induced protein with tetratricopeptide repeat (Ifit) 1, Ifit2, IRF3, and IRF7 were significantly elevated in the CCl4-induced liver fibrosis model. The gene discussed is USP18; the disease is Hepatic fibrosis.