Longitudinal tracking of clones in blood and cerebrospinal fluid from five neuromyelitis optica spectrum disorder (NMOSD) patients treated with anti-BCMA CAR-T cell therapy suggests that CD8+ cycling CAR-T cells play a predominant role in autoimmunity, primarily derived from CD8+ effector T cells at baseline prior to manufacturing (61). Here, CD8A is linked to Autoimmunity.