A 38-year-old woman with Scl70+ systemic sclerosis (SSc) and rapidly progressive non-specific interstitial pneumonia, treated with third-generation CD19 CAR-T cells, showed sustained amelioration of lung function and dramatic regression of imaging findings, including the disappearance of Fcγ-receptor-activating immune complexes (122). Here, CD19 is linked to systemic sclerosis.