ATR and cancer: GSEA pathway analysis revealed that ARIH2 is primarily involved in CD22-mediated BCR regulation, FcγR activation, FcγRI-mediated MAPK activation, FcγRIIIA-mediated IL-10 synthesis, initial triggering of complement, DNA damage and cellular response via ATR, cell cycle regulation, ECM regulation, pathways in cancer, and regulation of TP53 activity and other relevant pathways(Figure 10).