Additionally, our study has validated that the expression level of ARIH2 exhibits a significant positive correlation with the expression levels of immune checkpoint genes, including CD274 (PD-L1), HAVCR2, PDCD1 (PD-1), TIGIT, PDCD1LG2 (PD-L2), and SIGLEC15 in HCC. Here, SIGLEC15 is linked to hepatocellular carcinoma.