GSEA pathway analysis revealed that ARIH2 is primarily involved in CD22-mediated BCR regulation, FcγR activation, FcγRI-mediated MAPK activation, FcγRIIIA-mediated IL-10 synthesis, initial triggering of complement, DNA damage and cellular response via ATR, cell cycle regulation, ECM regulation, pathways in cancer, and regulation of TP53 activity and other relevant pathways(Figure 10). The gene discussed is BCR; the disease is cancer.