ARIH2 and hepatocellular carcinoma: In addition, the receiver operating characteristic (ROC) curve analysis was carried out on HCC patients in the TCGA and ICGC databases respectively, and the area under curve (AUC) values were determined to be 0.870 and 0.849 respectively, which demonstrated that the expression of ARIH2 exhibited a high level of accuracy in predicting the presence of the disease (Figures 2E-F).