A study elucidated that interferon-gamma (IFN-γ) released from CD8+ T cells can downregulate the expression levels of SLC3A2 and SLC7A11 on the tumor cell surface, thereby suppressing cystine uptake by tumor cells and ultimately promoting tumor cell lipid peroxidation and ferroptosis (54). The gene discussed is SLC3A2; the disease is neoplasm.