A 16-gene prognostic model (LATS2, LDHA, CKAP4, COBL, DSG2, MAPK4, AKAP12, HLF, CD69, BAIAP2L2, FSTL3, CXCL13, PTX3, SMO, KREMEN2, HOXC10) was established based on their strong association with T-cell activity and NSCLC prognosis. The gene discussed is SMO; the disease is non-small cell lung carcinoma.