MSLN and cancer: Additional targets include FRα and death receptors 4 and 5 (DR4/5), with studies showing that CAR-NK cells targeting these receptors effectively induce apoptosis in pancreatic cancer cells (139) Furthermore, mesothelin-targeted CAR-NK cells, when co-cultured with the STING agonist cGAMP, showed enhanced anti-cancer effects, both killing cancer cells and boosting immune responses (140).