KLF4 and breast carcinoma: (108) involving breast cancer, it was found that Kruppel-like factor-4 (KLF-4) recruits HDAC2 and HDAC3 at the VEGF promoter and represses their transcription, and that upregulation of VEGF in cancer is associated with loss of KLF-4-HDAC-mediated transcriptional repression.