ID2 and hepatocellular carcinoma: Additionally, the long non-coding RNA (lncRNA) ID2-AS1, which downregulates inhibitor of DNA binding 2 (ID2), enhanced ID2 transcription by blocking HDAC8 occupancy at the ID2 enhancer region, thereby inhibiting hepatocellular carcinoma (HCC) invasion and migration both in vitro and in vivo (131).