Additionally, the long non-coding RNA (lncRNA) ID2-AS1, which downregulates inhibitor of DNA binding 2 (ID2), enhanced ID2 transcription by blocking HDAC8 occupancy at the ID2 enhancer region, thereby inhibiting hepatocellular carcinoma (HCC) invasion and migration both in vitro and in vivo (131). This evidence concerns the gene HDAC8 and hepatocellular carcinoma.