HDAC1 and nasopharyngeal carcinoma: More recently, it was shown that DNTTIP1 represses DUSP2 gene expression by recruiting HDAC1 to its promoter, maintaining the deacetylated state of histone H3K27 (118), and downregulation of DUSP2 leads to abnormal activation of ERK signaling and elevated MMP2 levels, which promote metastasis in nasopharyngeal carcinoma (NPC).