We found a similar protective activity towards pneumolysin-induced hyperpermeability in HL-MVEC monolayers with the TIP peptide, as such supporting our published hypothesis that activation of endothelial ENaC represses NOX2 expression and activity and at least partially as such strengthens capillary barriers in pneumococcal pneumonia (Czikora et al., 2017; Romero et al., 2024). The gene discussed is CYBB; the disease is pneumococcal pneumonia.