In addition, for each cell type, we build default Random Forest (RF) (Fig. 6D) machine learning models (Pedregosa et al. 2011) to detect TGs with altered B from Controls to AD that may predict TF-TF links annotated (in Contextual IID) with neurodegenerative disease (class 1) or not (class 0). The gene discussed is TF; the disease is neurodegenerative disease.