EGR2 and Charcot-Marie-Tooth disease: Mutations affecting SC function are the most prevalent cause of demyelinating genetic neuropathy Charcot–Marie–Tooth disease (CMT) (Tao et al. 2019) and some affect major transcriptional TFs of SC differentiation like EGR2 and SOX10 (Srinivasan et al. 2012, Fröb and Wegner 2022).