Figure 5B shows 23 of 24 mSC-specific TFs in a mSC B ̄ network of 77 known PPIs (w > 0.01), where novel links are excluded for visual simplicity (corresponding figure for nmSCs: Supplementary Fig. S18A); POU3F1-EGR2 mSC cooperativity is extremely strong (B ̄ = 99.14, i.e. 99.14 percentile for mSCs), JUNB-ATF4 (B ̄ = 96.98) interact in PNS neoplasms like Schwannomas. BNC2’s regulatory activity in nmSCs may be attributed to the absence of its predicted repressor EGR2, which is ranked 10 of 20 mSC TFs for BNC2. The gene discussed is ATF4; the disease is peripheral nervous system neoplasm.