Some TF-TF pairs strongly cooperate (i.e. 50 ≤B≤100) exclusively in AD, such as: ZBTB14-ZNF281, FLI1-TAL1 for TMPRSS15; ZNF331-ZNF354A, MYEF2-SOX2 for ABCB5. This evidence concerns the gene ZNF281 and Alzheimer disease.