TMPRSS15 and Alzheimer disease: We explore TG-specific coordination B in Control versus AD stages for two AD risk genes (Jia et al. 2021, Bossaerts et al. 2022) (Fig. 6A): ABCB5 in Inhibitory Neurons (InNs) (t-test statistic: 22.6, P-adj < 4.5e−112) and TMPRSS15 in Mic (t: 36.1, P-adj < 4.8e−283); both TGs show notable increases in B in AD versus baseline Controls for the respective cell type.