(2023) experimentally verified that LPS activates caspase-11 in macrophages, induces pyroptosis during infection, activates atypical inflammatory vesicles via Gasdermin D (GSDMD) cleavage, and thus promotes inflammation in acute colitis by utilizing IL-1α in the colonic tissue.Defective autophagy may significantly influence the progression of IBD by disrupting intestinal homeostasis, altering the microbiota, impeding bacterial clearance, and exacerbating inflammation (Larabi et al., 2020). Here, GSDMD is linked to inflammatory bowel disease.