Further mechanistic studies revealed that berberine, the primary active component of berberine hydrochloride, significantly inhibits the proliferation and migration of cervical cancer HeLa cells by downregulating Bcl-2 expression through the TLR4/NF-κB signaling pathway, thereby promoting apoptosis (Hong et al., 2019). The gene discussed is NFKB1; the disease is cervical carcinoma.