Model 2, adjusted for SBP, HR, LDL-C, HDL-C, CREA, FIB, D-dimer, NT-proBNP, LVEF, NIHSS scores at admission, ESRS, mRS scores and pre-stroke CHA2DS2-VASc-60 scores, confirmed a significant independent association between the risk of in-hospital mortality and the high SII group. This evidence concerns the gene NPPB and Stroke.