Model 2, adjusted for SBP, HR, LDL-C, HDL-C, CREA, FIB, D-dimer, NT-proBNP, LVEF, NIHSS scores at admission, ESRS, mRS scores, and pre-stroke CHA2DS2-VASc-60 scores, confirmed the independent association between the high SII group and the risk of in-hospital mortality, and in-hospital mortality was 5.330 and 5.751 (P < 0.001) times higher in the high SII group. This evidence concerns the gene NPPB and stroke disorder.