NPPB and Stroke: After adjusting for SBP, HR, LDL-C, HDL-C, CREA, FIB, D-dimer, NT-proBNP, LVEF, NIHSS scores at admission, ESRS, mRS scores, and pre-stroke CHA2DS2-VASc-60 scores in Model 2, multivariate logistic regression analysis confirmed SII's independent association with in-hospital mortality risk, patients in the high SII category exhibited a 2.557 (95% CI: 1.154–5.665, P = 0.021) times higher likelihood of in-hospital mortality compared to those in the low SII category.