Apolipoprotein AI (Apo-AI), the preeminent structural constituent of high-density lipoprotein (HDL) in plasma, exhibits a well-established anti-inflammatory function across diverse inflammatory pathologies, encompassing lupus, Alzheimer's disease, and dermatitis.9, 10, 11 Furthermore, Apo-AI modulates dendritic cell maturation, thereby attenuating T cell activation, indicative of its indirect influence on T cell responses during inflammatory processes.12 The gene discussed is APOA1; the disease is early-onset autosomal dominant Alzheimer disease.