Although several studies have been conducted to understand the functional ability of ApoE variants, more research in this field is required for a better comprehension of how distinct ApoE isoforms affect Aβ aggregation and clearance in AD pathogenesis (Kim et al., 2009; Husain et al., 2021; Serrano-Pozo et al., 2021). The gene discussed is APOE; the disease is Alzheimer disease.