FMR1 and obesity due to melanocortin 4 receptor deficiency: The key bacterial genera related to obesity include Desulfovibrio, Lachnoclostridium, etc., while the key bacterial genera related to oxidative stress include Bifidobacterium, Lactobacillus, and Turicibacter, etc. In conclusion, FMRP effectively alleviates oxidative stress, improves lipid metabolism, and modulates the gut microbiota, highlighting its potential as a functional food for obesity management.