Low levels of GH and IGF-1 have been associated in different cohorts with endothelial dysfunction, increase in carotid intima-media thickness (CIMT), impaired coronary blood flow, coronary artery disease, congestive heart failure, left ventricular hypertrophy, arterial hypertension, myocardial infarction, and ischemic stroke (Caicedo et al., 2018). The gene discussed is GH1; the disease is myocardial infarction.