Therefore, this model would help to elucidate some main unknowns of asthma, for example, to identify the early pathogenesis of the disease, the kinetics of the humoral response from the first contact with the antigen to the development of sensitization where the antibody response changes from classic IgG and IgA to an IgE profile, to show how tissue remodeling is generated, including the molecular mechanisms by which the allergen crosses the mucosal barrier, etc. Here, IGHE is linked to asthma.