IGHE and asthma: Hence, this research aimed to validate the porcine model of respiratory hypersensitivity to a clinically relevant human allergen such Phleum pratense, using a novel sensitization protocol to induce the early development of the serum and mucosal response to the allergen, evaluating key clinical signs and features of an IgE mediated response to elucidate the suitability of the model for the study of asthma.