Genetic analyses of ACVRL1, ENG, and SMAD4 (in addition to EPHB4 and RASA1) are considered reasonable in all cases of high-flow intracerebral vascular malformations regardless of other HHT signs (Tas et al., 2022; Revencu et al., 2013b). This evidence concerns the gene SMAD4 and hereditary hemorrhagic telangiectasia.