In developmental syndromes, such as Beckwith-Wiedemann syndrome, dysregulation of the H19/insulin-like growth factor 2 (IGF2) imprinting control region leads to H19 downregulation and IGF2 overexpression, driving embryonic cell overgrowth and differentiation defects (Robbins et al., 2012). The gene discussed is H19; the disease is Beckwith-Wiedemann syndrome.