This study aimed to determine the prevalence and allele distribution of three TNF-α promoter gene SNPs loci – rs361525 (−238 G>A), rs1799964(−1031 T>C) and rs1800629 (−308 G>A) in women with cervical cancer (CC) and then evaluated the association between TNF-α SNPs and CC among women in Lagos, Nigeria. The gene discussed is TNF; the disease is cervical cancer.