Further studies revealed that D-mannose inactivates GSK3β, enhances the nuclear translocation of TFE3, upregulates the transcription levels of lysosomal biogenesis-related genes, and promotes lysosomal-mediated degradation of VEGFR2, thereby inhibiting angiogenesis and tumor growth in CRC (Figure 6). The gene discussed is TFE3; the disease is colorectal carcinoma.