The CD44 gene is composed of 20 exons, of which exons 1-5, 16-18, and 20 encode the standard form (CD44s), whereas exons 6-15 (corresponding to variant exons v1–v10) can undergo alternative splicing to alter the stem region conformation, influencing ligand binding and signaling properties, thereby generating functionally distinct various isoforms (CD44v).22 In contrast to the widespread expression of CD44s, the expression of CD44v isoforms is limited to specific epithelial cells and certain tumor cells. Here, CD44 is linked to neoplasm.