CXCR2 and type 1 diabetes mellitus: Besides to their role in the T cell activation and autoantigen presentation [198], macrophages secrete CXCR2 (CXC chemokine receptor 2) ligands as well as induce beta-cells by IL-1β to secrete CXCL (C-X-C motif chemokine ligand)1 and CXCL2 to recruit the neutrophils to the pancreas in T1D [206].