The mechanism analysis revealed that rhCC16 induced PGC‐1α expression via the AMPK/SIRT1 signalling pathway through α4β1 integrin and clathrin‐mediated endocytosis and promoted mitochondrial functional biogenesis, thereby improving mitochondrial function and ultimately delaying cell senescence and COPD progression. This evidence concerns the gene PPARGC1A and chronic obstructive pulmonary disease.