SIRT3 and Parkinson disease: Based on the UPDRS-III severity, PD patients were categorized into mild group (UPDRS-III < 32, n = 45) and moderate-severe group (UPDRS-III ≥ 32, n = 35), and no significant SIRT3 differences were found between the two groups [33.616(25.780, 56.976) vs. 36.068(25.630, 57.363) pg/ml, Z = − 0.254, p = 0.723] (Fig. 1d).