Meanwhile, the pathogenesis of depression is also related to SIRT3, which can activate the differentiation potential of aged neural stem cells and safeguard neurogenesis in aging and depression [19], and also improve depressive-like behaviors in rat by enhancing mitochondrial energy metabolism, decreasing the level of ROS, and suppressing neuroinflammation [20, 21]. This evidence concerns the gene SIRT3 and major depressive disorder.