In the TCGA cohort, FXR1 and ACTR3, key genes in the tight junction and NSCLC pathways targeted by cDHPs were significantly positively associated with IL-35, and FXR1 was positively associated with key driver genes for NSCLC development, while ACTR3 was positively associated with EMT-related genes. The gene discussed is ACTR3; the disease is non-small cell lung carcinoma.