However, the relationship of FXR1-IL-35-ACTR3 axis the relationship of in the current experiments needs to be validated by in-depth molecular biology experiments, and the combination of cDHPs with PD-1/PD-L1 needs to continue to be validated by animal experiments, contributing to a more profound understanding of the application of herbal anti-tumor immunotherapy, which will also be our next step. Here, ACTR3 is linked to neoplasm.