Additionally, SFN combined with 5-aza-2’-deoxycytidine and trichostatin A significantly reduced the CpG methylation levels in the NRF2 promoter region and inhibited the protein expression of DNA methyltransferase 1 (DNMT1), thereby promoting NRF2 expression, which may play a preventive role in colon cancer [151]. Here, NFE2L2 is linked to malignant colon neoplasm.