Among the 4 most common tumor types, HCC, RCC, bladder cancer (BC), and head and neck cancer (HNC) in our cohort, baseline IL-8, IL-13, IL-17f, CCL5, CXCL9, CXCL10, VEGF-α, and GM-CSF differed between two of the tumor types, and IL-8, IL-17f, and CXCL10 differed significantly among the four tumor types (Supplementary Fig. 2A, B, P < 0.05). This evidence concerns the gene CXCL8 and renal cell carcinoma.