TRPV4 and skeletal dysplasia: Skeletal dysplasia does not usually cause multiple joint flexures, and multiple congenital joint contractures represent an overlap between the neuromuscular and skeletal phenotypes of autosomal dominant TRPV4 disorders.[20] It might be difficult to differentiate between neurological symptoms caused by TRPV4 variations in patients with severe skeletal dysplasia because severe skeletal manifestations can compress nerves and result in neurological symptoms.