BRD2 and cryptorchidism: For the ultimate effect of treatment, a smaller initial testicular volume or cryptorchidism at the start of treatment is associated with a smaller final testicular volume.[16] A period of FSH pretreatment before hCG + FSH or GnRH pump treatment to increase the number of Sertoli cells may also increase the final testis volume.[17] In addition, the degree of olfactory dysfunction may also be related to the final testicular volume and spermatogenesis.