After receiving pulsatile GnRH pump therapy, the testicular volume, length, circumference, as well as LH, FSH, and testosterone levels in patients with KS significantly improve, and inhibin B levels also increase to some extent.[13] In terms of safety, no other significant adverse reactions such as injection site redness, acne, or gynecomastia are observed, except for mild local injection site pain in a small number of patients. Here, PLOD1 is linked to Gynecomastia.