The expression of ARNTL was negatively correlated with the expression of ATG9B-4 in the patients with liver cancer (P = .0195) (Fig. 2D), while there was no significant correlation between ARNTL and ATG9B-4 in normal tissues from patients (P = .3580) (Figure S2, Supplemental Digital Content, https://links.lww.com/MD/O712), which manifested that ARNTL was negatively regulated by ATG9B-4 in the patients with liver cancer. This evidence concerns the gene BMAL1 and liver cancer.