There, it binds to the promoters of genes involved in antioxidant stress, thereby facilitating their expression and bolstering the cell’s antioxidant defense mechanisms.[7] Activation of the NRF2 pathway has been implicated in diverse physiological and pathological processes,including cancer,[8] liver diseases,[9] diabetes,[10] and sepsis.[11]. This evidence concerns the gene NFE2L2 and Sepsis.