TNF and Sepsis: Astragaloside IV, derived from the traditional Chinese herb Astragalus membranaceus, has gained attention in biomedical research due to its varied pharmacological properties, including anti-inflammatory, antioxidant, immunomodulatory, and hepatoprotective effects.[72] In Sepsis-related liver injury, AS-IV inhibits lipopolysaccharide-induced NLRP3 inflammasomes and reverses LPS-induced pro-inflammatory cytokine IL-1β by activating the SIRT1/Nrf2 pathway and decreasing TNF-α and IL-6 expression.