Nrf2 exerts its anti-inflammatory effects by modulating the expression of an array of inflammatory factors.[25] Furthermore, Nrf2 is intricately involved in regulating cell survival and apoptosis.[26] Research has evidenced that activation of the Nrf2 signaling pathway can bolster cell survival rates and confer protection against various diseases such as pneumonia,[27] myocardial infarction,[28] and stroke.[29] In summary, the Nrf2 signaling pathway intricately regulates cellular self-protective mechanisms by modulating antioxidant response, anti-inflammatory responses, and cell survival. The gene discussed is NFE2L2; the disease is stroke disorder.