NFE2L2 and Sepsis: Beyond its protective effects against tissue damage instigated by oxidative stress and inflammation, Nrf2 activation augments the antibacterial capacity of macrophages, thereby exerting a protective influence on the onset and progression of sepsis.[40,41] In conclusion, the Nrf2 pathway assumes a pivotal role in mitigating inflammation, oxidative stress, and organ damage attendant upon sepsis.