We observed a nonlinear dose–response relationship between MCV and 28-day mortality in Fig 2 (after adjusting age; gender; BMI; temperature; respiratory rate; heart rate; MAP; acute physiology score III; apache IV score; AIDS; hepatic failure; metastatic cancer; immunosuppression; albumin; lactate; platelets; hemoglobin; RDW; white blood cell count). This evidence concerns the gene ALB and AIDS.