TLR3 and colorectal carcinoma: Similarly, Zhao et al. [41] explored the molecular characteristics of PANoptosis in CRC prognosis and developed a predictive model incorporating four PANoptosis-related genes: TIMP1, CDKN2A, CAMK2B, and TLR3. The ICDRS offers a distinct advantage over existing prognostic indicators in assessing CRC patient outcomes.