Investigations have shown that (6), a natural bioactive monoterpenoid, exerts a potential anticancer effect on metastatic melanoma cells (B16-F10) due to their cell inhibition through downregulation of survivin protein, which activates the extracellular signal-regulated kinases (ERK)/mitogen-activated protein kinase phosphatase-3 (MKP-3)/proteosome pathway [38]. The gene discussed is DUSP6; the disease is melanoma.