CD4 and gingival fibromatosis-progressive deafness syndrome: In addition, GFD was characterized by the downregulation of genes responsive to IFNγ and IFNα in conventional CD4+ and CD8+ T cells, the upregulation of STAT5 signaling in Tregs, and the upregulation of pathways associated with proliferation in CD4+ T cells, CD8+ T cells, NK cells, and unconventional subsets (Figure 5F).