FGFR2 and Apert syndrome: For that, we selected the cancer-associated FGFR2 p.N550K (Stehbens et al., 2018), and also the Apert syndrome p.P253R (Wilkie et al., 1995), the Crouzon syndrome p.C342R (Reardon et al., 1994), the bent bone dysplasia p.M391R (Merrill et al., 2012), and the kinase-dead p.A649T (Shams et al., 2007).