Cluster 0 showed high expression of genes and pathways implicated in transcriptional regulation, protein synthesis, signal transduction, and metabolic pathways such as Satb1, Dmxl1, Pgap1, Stap1, Ebf1, and Bach2 (Figure 3D, top), suggesting these cells are engaged in regulatory activities and heightened activation in MASH-driven HCC (Figure 3D, bottom). The gene discussed is BACH2; the disease is hepatocellular carcinoma.