SQSTM1 and hepatocellular carcinoma: Notably, the MUP-uPA mice showed evidence of profound HCC development (Figure 1H), including an increased number of tumors (Figure 1I), higher expression of the tumor-associated marker AFP (Figure 1J), and elevated expression of the tumorigenesis-related genes Sqstm1 (p62) and Afp (Figure 1K).