Functional enrichment analyses of the KSS target genes revealed the critical role of inflammatory, hypoxia sensing, angiogenic, and estrogen signaling pathways in mediating the protective effects of KSS against NAFLD, including the signaling pathways of TLR, TNF, NF-kappa B, hypoxia-inducible factor-1 (HIF-1), vascular endothelial growth factor (VEGF), and E2. This evidence concerns the gene TNF and metabolic dysfunction-associated steatotic liver disease.