Targeting this motif in PLK4 with small molecules has been considered a therapeutic strategy for blocking centriole duplication in cancers that rely on PLK4‐driven centrosome amplification, which is frequently observed in certain cancers, particularly breast cancer and melanoma (Figure 2D) (Chan 2011; Denu et al. 2018; Denu et al. 2016; Zhao and Wang 2019). This evidence concerns the gene PLK4 and cancer.