In hepatocellular carcinoma (HCC), TuBG1 overexpression was linked to poor prognosis, and its silencing led to increased ATR, p-P53, and apoptosis-related protein expression, reducing proliferation by M4344 (16). In ovarian cancer, SLFN11 downregulation contributed to cisplatin resistance, which was reversible by HDAC inhibition. Here, ATR is linked to hepatocellular carcinoma.