AZD1390 (7) inhibits ATM-dependent DNA repair, enhances radiotherapy efficacy by inhibiting the repair of radiation-induced damage, and effectively penetrates the blood-brain barrier to target glioblastoma tumours, NSCLC and soft tissue sarcoma directly. Elevate anti-tumour effects in breast cancer cell lines by combination with cisplatin. Here, ATM is linked to soft tissue sarcoma.