The higher representative ADC values of our cohort than those of the PC cases in the first screening cohort of the PROBASE trial of 50-yr-old men with PSA ≥3 ng/ml and that no case was classified to have PI-RADS 4 or 5 indicate a collective most likely without clinically significant PC (csPC), although the present study lacks a histopathological correlation [13]. Here, KLK3 is linked to pachyonychia congenita.