GNRH1 and systemic lupus erythematosus: During the light phase, the function of biosynthesis of 12-,14-and 16-membered macrolides, GABAergic synapse, glutamatergic synapse and systemic lupus erythematosus was significantly upregulated, while the endocytosis, GnRH signaling pathway, photosynthesis and Ras signaling pathway was significantly downregulated compared to the dark phase (Figure 5B).