FGFR3 and achondroplasia: Mice carrying the FGFR3 mutation that leads to ACH display shortened long bones with disarranged chondrocytes in growth plates and spinal stenosis, as well as cranial deformities characterized by dome-shaped skulls, which closely resemble the phenotypes of ACH patients,39,40 indicating the crucial role of FGFR3 in regulating of endochondral bone formation.