By utilizing mouse models of osteoarthritis, in which FGFR3 is selectively deleted or activated, we have demonstrated that FGFR3 plays an essential role in delaying the progression of osteoarthritis in temporomandibular and knee joints, partially by suppressing IHH signaling in articular chondrocytes.91 The gene discussed is FGFR3; the disease is osteoarthritis.