,48 FGF2 treatment caused an elevation in the expression of p21, leading to the formation of complexes involving cyclin D2-Cdk4-p21, cyclin D2-Cdk2-p21, and cyclin E-Cdk2-p21, and reducing the activity of cyclin-dependent kinase 2 (Cdk2) and cyclin E-dependent kinases in rat chondrosarcoma cells.49 This evidence concerns the gene FGF2 and chondrosarcoma.