Cystic kidney dysplasia, hydronephrosis due to urethral stenosis, chronic renal insufficiency, diabetes requiring insulin at 13 years, pancreatic hypoplasia with progressive exocrine pancreatic failure, inguinal hernia, abdominal testis, joint contractions, microcephaly, hypercholesterolemia, hypertriglyceridemia. Here, INS is linked to chronic kidney disease.